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Updated: Jan 18, 2026

Evaluating the Effect of SASP Factors on the Proliferation of Cancer Cells Using a Comparative Analysis of Three Distinct Methodologies
Published on: September 19, 2025
Multifactorial conceptual model of cancer-related accelerated aging
Lisa Morse1,2, Sandra Weiss3, Christine S Ritchie4,5
1School of Nursing, University of California, San Francisco, CA, USA. lisa.morse@ucsf.edu.
Cancer-related accelerated aging can lead to chronic diseases and reduced quality of life. The Multifactorial Model of Cancer-related Accelerated Aging (MMCRAA) framework helps identify at-risk patients and guide personalized care.
Area of Science:
- Gerontology
- Oncology
- Public Health
Background:
- Cancer survivors often experience accelerated aging, leading to chronic diseases and diminished quality of life.
- This phenomenon impacts long-term patient well-being and healthcare needs.
Purpose of the Study:
- To introduce the Multifactorial Model of Cancer-related Accelerated Aging (MMCRAA).
- To provide a framework for understanding and addressing cancer-related aging.
- To guide clinical practice and research in oncology.
Main Methods:
- This review synthesizes existing evidence and theoretical frameworks.
- The Multifactorial Model of Cancer-related Accelerated Aging (MMCRAA) is presented as a conceptual framework.
- The model integrates person, behavioral, biological, treatment, symptom, and life course factors.
Main Results:
- The MMCRAA framework identifies key factors contributing to cancer-related accelerated aging.
- The model highlights the interconnectedness of various influences on aging in cancer patients.
- Empirical evidence supports the components of the MMCRAA.
Conclusions:
- The MMCRAA offers a comprehensive approach to understanding accelerated aging in cancer survivors.
- Clinicians and researchers can utilize the MMCRAA to identify high-risk individuals.
- The model can inform personalized treatment strategies and intervention development for improved patient outcomes.
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