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Related Experiment Video

Updated: Jan 18, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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[Ulcerative Colitis-Associated Cancer Resembling a Submucosal Tumor-A Case Report].

Motoaki Iga1, Yoshifumi Shimada, Hikaru Ozeki

  • 1Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|January 17, 2026
PubMed
Summary
This summary is machine-generated.

A patient with ulcerative colitis developed rectal cancer, presenting as a stenotic lesion. Early detection and robot-assisted surgery led to successful treatment with no signs of recurrence.

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Area of Science:

  • Gastroenterology and Oncology
  • Colorectal Surgery

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease that increases the risk of colorectal cancer.
  • Distinguishing between chronic inflammation and malignancy in UC patients can be challenging, especially with atypical presentations.

Purpose of the Study:

  • To report a case of rectal cancer in a patient with long-standing ulcerative colitis.
  • To highlight the diagnostic challenges and successful management of a submucosal tumor-like lesion in the rectum.

Main Methods:

  • Case presentation of a 63-year-old male with ulcerative colitis.
  • Diagnostic workup including colonoscopy, biopsy, 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), and tumor marker analysis (carcinoembryonic antigen).
  • Surgical management using robot-assisted low anterior resection followed by histopathological examination.

Main Results:

  • Colonoscopy revealed a stenotic rectal lesion with a submucosal tumor-like protrusion.
  • Initial biopsy was inconclusive for neoplasia, but FDG uptake and rising CEA levels indicated malignancy.
  • Postoperative pathology confirmed invasive rectal carcinoma associated with ulcerative colitis (UC-III).
  • The patient achieved no evidence of disease recurrence 2 years after surgery.

Conclusions:

  • Rectal cancer can present atypically in ulcerative colitis patients, mimicking inflammatory lesions.
  • Multimodal diagnostic approaches are crucial for accurate diagnosis.
  • Robot-assisted surgery offers a viable treatment option for rectal cancer in UC patients, achieving favorable outcomes.