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[Radiation-Associated Angiosarcoma of the Breast-A Case Report]
Noriko Maeda1, Yukiko Nagashima, Hiroyuki Takasu
1Dept. of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|January 17, 2026
Summary
Radiation-induced angiosarcoma (RIAS) of the breast is a rare cancer. Early diagnosis and extensive surgery are key for successful treatment of this aggressive tumor.
Area of Science:
- Oncology
- Surgical Oncology
- Radiotherapy
Background:
- Radiation-induced angiosarcoma (RIAS) is a rare breast malignancy.
- It typically arises after breast-conserving therapy, including surgery and radiation.
Purpose of the Study:
- To present a case of RIAS in a patient previously treated for breast cancer.
- To highlight the diagnostic and management strategies for RIAS.
Main Methods:
- Case report of a 70-year-old woman with RIAS.
- Diagnostic workup included physical examination, ultrasound, CT, and MRI.
- Treatment involved wide surgical resection and latissimus dorsi flap reconstruction.
Main Results:
- A 65 mm angiosarcoma was confirmed with negative surgical margins.
- The patient experienced delayed wound healing, managed with hyperbaric oxygen therapy.
- No recurrence was noted at 6-month follow-up.
Conclusions:
- RIAS requires early diagnosis and aggressive surgical management.
- Multidisciplinary care, including reconstructive surgery, is crucial for favorable outcomes.
- This case underscores the importance of vigilance for RIAS post-radiation therapy.
