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[A Case of Isolated Splenic Metastasis after Colon Cancer Surgery]
Akinao Kaneta1, Miku Ueno, Hiroshi Nakano
1Dept. of Surgery, Fukushima Rosai Hospital.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|January 17, 2026
Summary
This case study highlights a rare instance of isolated splenic metastasis from colon cancer. Surgical resection of the splenic tumor led to a decline in tumor markers, but liver metastases later appeared, emphasizing the complexity of managing such rare occurrences.
Area of Science:
- Oncology
- Surgical Oncology
- Gastrointestinal Cancer Research
Background:
- Colon cancer presents unique metastatic patterns.
- Isolated splenic metastasis from colon cancer is exceptionally rare.
- Systemic nature of splenic metastases complicates treatment.
Purpose of the Study:
- To report a case of isolated splenic metastasis from descending colon cancer.
- To discuss the diagnostic and therapeutic challenges of rare splenic metastases.
- To evaluate the role of splenectomy in managing isolated splenic metastasis.
Main Methods:
- Resection of descending colon cancer.
- Chemotherapy regimens (IRIS + bevacizumab, CAPOX + bevacizumab).
- Splenectomy for isolated splenic metastasis.
- Histopathological examination and tumor marker monitoring.
Main Results:
- Patient diagnosed with Stage IIb colon cancer (T4aN0M0).
- Developed isolated splenic metastasis 6 months post-colectomy.
- Splenectomy resulted in a marked decline in tumor markers.
- Multiple liver metastases observed 6 months after splenectomy.
Conclusions:
- Resectable isolated splenic metastasis warrants consideration as a multidisciplinary treatment option.
- Multidisciplinary approach should include adjuvant chemotherapy and optimized surgical timing.
- Early detection and tailored treatment strategies are crucial for rare metastatic presentations.
