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Pretreatment Circulating Vascular Biomarkers Predict Cancer Therapy-Related Cardiac Dysfunction During HER2+ Breast

Dakota Gustafson1, Priya Mistry1, Crizza Ching2

  • 1Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

JACC. Cardiooncology
|January 17, 2026
PubMed
Summary

Predicting cancer therapy-related cardiac dysfunction (CTRCD) risk in HER2-positive breast cancer patients is crucial. Pretreatment endothelial and inflammatory biomarkers show promise in identifying patients at high risk for CTRCD during chemotherapy.

Keywords:
angiopoeitin-2, biomarkersbreast cancercancer therapy–related cardiac dysfunctioncardio-oncologyendotheliuminflammationmachine learningmicroRNAmyeloperoxidasevascular

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