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Experimental and computational dosimetry in an integrated workflow for remote audits in Ir-192 interstitial
Eleftherios P Pappas1, Vasiliki Peppa1,2, Alexandra Drakopoulou1
1Medical Physics Laboratory, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Journal of Applied Clinical Medical Physics
|January 17, 2026
Summary
This study developed a remote dosimetry audit for Ir-192 brachytherapy, combining experimental and computational methods. The integrated approach enhances the reliability of audits for high-dose-rate treatments.
Area of Science:
- Medical Physics
- Radiation Oncology
- Dosimetry
Background:
- High Dose Rate (HDR) Ir-192 brachytherapy requires accurate dose delivery.
- Remote dosimetry audits are crucial for quality assurance in radiation therapy.
- Existing audit methods may lack comprehensive validation.
Purpose of the Study:
- To develop and pilot a comprehensive remote dosimetry audit protocol for Ir-192 HDR interstitial brachytherapy.
- To integrate independent experimental and computational dosimetry procedures into a unified workflow.
- To assess the feasibility and reliability of the developed remote audit system.
Main Methods:
- A water-equivalent phantom with dosimeters (OSLDs, radiochromic films) and catheters was designed.
- Independent experimental dosimetry and computational Monte Carlo (MC) simulations were performed.
- Treatment Planning System (TPS) calculations (TG43, MBDCA) were compared using 3D Gamma Index (GI) and dose difference maps.
Main Results:
- The pilot study was completed within 10 days.
- Excellent agreement was observed between MBDCA predictions and experimental/MC results.
- TG43 calculations showed a systematic overestimation (+2.16%) compared to MC results due to scatter and material differences.
Conclusions:
- The developed protocol is suitable for remote Ir-192 audits with acceptable uncertainties.
- Combining experimental and computational dosimetry strengthens audit reliability.
- An integrated dosimetry protocol offers advantages for comprehensive auditing programs.
