Contaminating the evidence: the reproducibility crisis and fraud in infectious disease research

Irreproducible and fraudulent research is an enormous problem that decreases the public's trust in biomedical science. Unfortunately, infectious disease (ID) research has not escaped the reproducibility crisis and investigator maleficence. This article describes the scope of the problem, explores some of the reasons why investigators commit research fraud, and discusses the surprising lack of oversight by relevant stakeholders including the National Institutes of Health (NIH), scientific journals, and academic institutions. Finally, a novel solution for tackling fraud in ID research is proposed.