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Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus
Published on: May 31, 2020
Genomic epidemiology of dengue virus 2 and 3 reveals repeated introductions and exportations of several lineages in
Ricardo Rivero1, Vaneza Tique-Salleg2, Daniel Echeverri-De la Hoz3
1Paul G. Allen School for Global Health, Washington State University, Pullman, WA 99164, USA; Instituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia.
Abstract:
Dengue fever, a major mosquito-borne viral disease, is transmitted by Aedes mosquitoes and poses a significant global health burden. Despite extensive research, the spatiotemporal dynamics of dengue virus (DENV) lineages in Colombia remain understudied. Here, we analyze 11,443 complete genome sequences from Colombia and the Americas to map the genomic epidemiology of DENV-2 and DENV-3. Phylogeographic reconstruction revealed multiple independent introductions and exportations of the DENV-2 II and III lineages, as well as the DENV-3 lineage III_C.2, underscoring Colombia's critical role as both a source and a sink of viral traffic within the Americas. Antigenic profiling demonstrated distinct clustering of emergent lineages in antigenic space, consistent with immune-escape-driven turnover. These results highlight the necessity of sustained, high-resolution genomic surveillance to guide targeted public health interventions and mitigate dengue transmission across the region.
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