Effect of mechanical relaxation of 3D-printed collagen-based extracellular matrix on behavior of neural cell

This review explores how mechanical relaxation in 3D-printed collagen-based extracellular matrices (CECMs) impacts the behavior of neural cells. 3D printing technology has significantly revolutionized tissue engineering, enabling the creation of CECMs with accurate control over their mechanical properties. Current studies show that the mechanical relaxation of these 3D-printed CECMs can significantly influence the behavior of embedded neural cells. This review synthesizes current knowledge on this topic, discussing the methods used for inducing mechanical relaxation in 3D-printed CECM, and how these changes affect neural cell morphology, proliferation, differentiation, and function. The possible implications of these findings for neural tissue engineering and regenerative medicine are also discussed. This review seeks to elucidate the relationship between mechanical relaxation in 3D-printed extracellular matrices (ECM) and brain cell activity, thereby laying the groundwork for enhanced techniques in neural tissue repair and regeneration.