Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Fermentation01:23

Microbial Fermentation

1.4K
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
1.4K
Other Glycolytic Pathways01:24

Other Glycolytic Pathways

834
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
834

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Competitive Metabolism of Terephthalic Acid by a Consortium of Native and Engineered Bacteria.

ACS synthetic biology·2026
Same author

Minimum viable products in precision fermentation: defining translational milestones for food biotechnology.

Current opinion in biotechnology·2026
Same author

Engineering a robust cell-surface display platform in the multi-stress-tolerant yeast Issatchenkia orientalis.

Applied microbiology and biotechnology·2026
Same author

Xylose metabolic engineering of Issatchenkia orientalis for 3-hydroxypropionic acid production from cellulosic hydrolysate without nutrient supplementation.

Bioresource technology·2026
Same author

Functional Dipeptide Production by Immobilized Enzyme on Yeast Cell Surface.

Journal of microbiology and biotechnology·2026
Same author

All You Can Eat Yeast: Substituting Hexose Transporters With AtSWEET7 Alleviates Glucose Repression, Enabling Simultaneous Utilization of Sugars in Renewable Feedstocks.

Biotechnology and bioengineering·2026
Same journal

Structural inequalities in global antimicrobial resistance governance.

Trends in microbiology·2026
Same journal

Environmental microbes as modulators of plant volatile landscapes: Implications for plant-insect chemical communication.

Trends in microbiology·2026
Same journal

Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools.

Trends in microbiology·2026
Same journal

Cronobacter spp.

Trends in microbiology·2026
Same journal

Anaerobic lignin deconstruction: A game changer for lignocellulosic biorefineries.

Trends in microbiology·2026
Same journal

Critical role of the inflammatory rheostat in influenza-associated pulmonary aspergillosis.

Trends in microbiology·2026
See all related articles

Related Experiment Video

Updated: Jan 19, 2026

Assembly and Quantification of Co-Cultures Combining Heterotrophic Yeast with Phototrophic Sugar-Secreting Cyanobacteria
05:44

Assembly and Quantification of Co-Cultures Combining Heterotrophic Yeast with Phototrophic Sugar-Secreting Cyanobacteria

Published on: December 27, 2024

1.5K

A tunable microbial factory for rare sugar coproduction.

Stephan Lane1, Yong-Su Jin2

  • 1Department of Food Science, Cornell University, Ithaca, NY 14853, USA.

Trends in Microbiology
|January 17, 2026
PubMed
Summary
This summary is machine-generated.

Researchers created a microbial platform to convert d-glucose into rare sugars like d-sedoheptulose and d-mannose. This platform advances the study of C7 sugar metabolism and natural product synthesis.

Keywords:
biotransformationd-sedoheptulosed-sedoheptulose-7-phosphatephosphataserare sugar

More Related Videos

Light-Controlled Fermentations for Microbial Chemical and Protein Production
08:37

Light-Controlled Fermentations for Microbial Chemical and Protein Production

Published on: March 22, 2022

4.6K
In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast
06:53

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

Published on: February 21, 2025

892

Related Experiment Videos

Last Updated: Jan 19, 2026

Assembly and Quantification of Co-Cultures Combining Heterotrophic Yeast with Phototrophic Sugar-Secreting Cyanobacteria
05:44

Assembly and Quantification of Co-Cultures Combining Heterotrophic Yeast with Phototrophic Sugar-Secreting Cyanobacteria

Published on: December 27, 2024

1.5K
Light-Controlled Fermentations for Microbial Chemical and Protein Production
08:37

Light-Controlled Fermentations for Microbial Chemical and Protein Production

Published on: March 22, 2022

4.6K
In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast
06:53

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

Published on: February 21, 2025

892

Area of Science:

  • Microbiology
  • Metabolic Engineering
  • Synthetic Biology

Background:

  • d-Sedoheptulose is a rare C7 sugar with potential applications in food and pharmaceuticals.
  • Current methods for producing rare sugars are often inefficient or costly.
  • Understanding the metabolic pathways of rare sugars is crucial for their biotechnological production.

Purpose of the Study:

  • To develop a tunable microbial platform for the efficient production of d-sedoheptulose and d-mannose.
  • To establish a foundation for exploring the metabolism of other rare C7 sugars.
  • To enable the production of natural products derived from d-sedoheptulose-7-phosphate.

Main Methods:

  • Engineered microbial strains utilizing d-glucose as a substrate.
  • Metabolic pathway engineering to introduce and optimize sugar biosynthesis.
  • Fermentation and downstream processing to quantify product yields.

Main Results:

  • Successful conversion of d-glucose into d-sedoheptulose and d-mannose.
  • Achieved production levels relevant for food industry applications.
  • Demonstrated tunability of the microbial platform for potential optimization.

Conclusions:

  • The developed microbial platform offers a promising route for producing valuable rare sugars.
  • This work provides a starting point for further research into C7 sugar metabolism.
  • The platform has the potential to unlock novel natural products derived from d-sedoheptulose-7-phosphate.