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Related Experiment Video

Updated: Jan 20, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
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Predicting Perimetric Glaucoma Development in Suspects Using Widefield OCT-Based Risk Scores.

Huiyuan Hou1, Takashi Nishida2, Evan Walker2

  • 1Topcon Healthcare, Oakland, New Jersey.

Ophthalmology. Glaucoma
|January 18, 2026
PubMed
Summary
This summary is machine-generated.

New optical coherence tomography (OCT)-based risk scores predict glaucoma development in glaucoma suspects. These integrated metrics, using retinal layer thickness, improve risk stratification for early intervention.

Keywords:
GlaucomaOCTProgressionRisk predictionWide scan

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma suspect eyes require accurate risk stratification for timely intervention.
  • Predictive models for glaucoma development are crucial for clinical management.

Purpose of the Study:

  • To assess the predictive capability of baseline wide-field optical coherence tomography (OCT)-based risk scores for developing perimetric glaucoma.
  • To evaluate the clinical utility of these OCT-derived risk scores in glaucoma suspects.

Main Methods:

  • A prospective cohort study included 257 glaucoma suspect eyes with normal visual fields (VF).
  • Wide-field OCT scans (12mmx9mm) captured macular and peripapillary inner retinal layer thickness.
  • Three OCT-based risk scores were calculated; glaucoma progression was defined by repeatable abnormal VF results.

Main Results:

  • Over a mean follow-up of 2.8 years, 80 eyes progressed to perimetric glaucoma.
  • OCT-based risk scores were significant predictors of progression in multivariable models.
  • Risk scores showed superior predictive performance (higher area under ROCs) and clinical utility (higher net benefit via DCA) compared to individual OCT parameters.

Conclusions:

  • Baseline OCT-based risk scores, integrating peripapillary and macular thickness, effectively predict future perimetric glaucoma development.
  • These integrated risk scores offer a valuable tool for risk stratification and may guide early intervention in glaucoma suspects.