Related Experiment Video

Updated: Jan 20, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

10.4K

The Role of Stem Cell Transplantation in Hodgkin Lymphoma

Hanan Alharthy1, Sairah Ahmed2

  • 1Division of Cancer Medicine, Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 429, Houston, TX 77030, USA.

Hematology/Oncology Clinics of North America
|January 18, 2026
PubMed

Stem cell transplantation remains a cornerstone in managing relapsed/refractory classic Hodgkin lymphoma, though its role is evolving with the integration of targeted therapies. Autologous stem cell transplantation achieves cure rates of 50% to 60%, enhanced significantly with the introduction of novel agents including brentuximab vedotin and checkpoint inhibitor-based salvage and consolidation regimens. Allogeneic transplantation with reduced-intensity conditioning offers curative potential for patients with disease that relapses after autologous stem cell transplantation. This article reviews the evidence for autologous and allogeneic stem cell transplantation, their integration with novel agents, and the emerging transplant-sparing strategies.

Keywords:
Allogeneic stem cell transplantAutologous stem cell transplantBrentuximab vedotinCheckpoint inhibitionHodgkin lymphomaNovel therapy Hodgkin lymphomaStem cell transplantation

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