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Related Concept Videos

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Related Experiment Video

Updated: Jan 20, 2026

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration
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Lesion stratification with intracoronary imaging.

Michael McGarvey1,2, Kalpa De Silva2,3, Thomas R Keeble4,5

  • 1Department of Cardiology, King's College Hospital NHS Foundation Trust, London, United Kingdom.

Eurointervention : Journal of Europcr in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
|January 19, 2026
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Summary

Intracoronary imaging guidance for percutaneous coronary intervention (PCI) enhances patient outcomes, especially for complex cases. This technology offers detailed plaque insights, potentially revolutionizing interventional cardiology.

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Last Updated: Jan 20, 2026

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Interventional Cardiology

Background:

  • Intracoronary (IC) imaging-guided percutaneous coronary intervention (PCI) demonstrates superior clinical outcomes compared to angiography alone, particularly in high-risk patients.
  • Recent Class I recommendations support IC imaging for PCI in left main stem or complex lesions, indicating its growing adoption as a standard of care.

Purpose of the Study:

  • To review the emerging application of IC imaging for morphology-guided PCI.
  • To explore the potential of IC imaging in identifying high-risk lesions for targeted therapies.
  • To consider the integration of artificial intelligence (AI) for automated image interpretation and combined physiological/morphological assessment.

Main Methods:

  • Review of current literature and emerging trends in IC imaging and AI for PCI.
  • Analysis of the role of IC imaging in plaque characterization and lesion stratification.
  • Discussion of future prospects for integrated imaging and AI in interventional cardiology.

Main Results:

  • IC imaging provides high-fidelity intracoronary data on plaque composition and distribution.
  • Combining IC imaging with AI and computational fluid dynamics can lead to advanced lesion stratification.
  • Morphology-guided PCI informed by IC imaging has the potential to improve patient management.

Conclusions:

  • IC imaging is pivotal for enhancing PCI, offering detailed morphological insights.
  • The integration of AI with IC imaging promises a future paradigm shift in assessing coronary lesions.
  • IC imaging-guided PCI holds the potential to transform interventional cardiology practices beyond the cath lab.