Related Experiment Video

Updated: Jan 20, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Isolated Right Ventricular Hypertrophic Cardiomyopathy Mimicking an Intramural Mass in a 13-Year-Old Male

Hu Tingting1, Ma Guotao2, Li Xiaona3

  • 1Department of Cardiology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing China.

Clinical Case Reports
|January 19, 2026
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) typically affects the left ventricle. This case highlights a rare instance of severe right ventricular hypertrophy causing right ventricular outflow tract (RVOT) obstruction, a unique presentation of HCM.

Area of Science:

  • Cardiology
  • Pathology
  • Medical Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary disease of the left ventricle.
  • Right ventricular hypertrophy and outflow tract obstruction are uncommon manifestations of HCM.

Purpose of the Study:

  • To present a rare case of hypertrophic cardiomyopathy presenting with significant right ventricular hypertrophy and outflow tract obstruction.
  • To discuss the diagnostic challenges and considerations for RVOT-type HCM.

Main Methods:

  • Review of clinical presentation, diagnostic imaging (echocardiography, MRI), and pathological findings.
  • Intraoperative observation and histopathological examination were crucial for diagnosis.

Main Results:

  • The case presented with severe right ventricular hypertrophy leading to significant right ventricular outflow tract obstruction.
  • Hypertrophic myocardium in the right ventricle mimicked intramural masses, complicating diagnosis.

Conclusions:

  • Right ventricular outflow tract obstruction is a rare but possible complication of hypertrophic cardiomyopathy.
  • Accurate diagnosis of RVOT-type HCM requires a combination of advanced imaging, intraoperative assessment, and pathological analysis.

Keywords:
adolescentcardiac imaginghypertrophic cardiomyopathymimicking massright ventricular outflow tract

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