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Effects of targeted therapy for RCC on LUTS in elderly male patients

Li Xiaona1, Ren Hailin2

  • 1Molecular Pathology Laboratory of Pathology Department, The People's Hospital of Qinghai, Xining, P.R.China.

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
|June 13, 2025
PubMed
Abstract

Insights

Targeted drugs for renal cell carcinoma may worsen lower urinary tract symptoms (LUTS) in elderly men. Increased age and longer treatment duration are linked to a higher risk of LUTS development and exacerbation.

Area of Science:

  • Oncology
  • Urology
  • Geriatrics

Background:

  • Renal cell carcinoma (RCC) is a significant health concern in elderly men.
  • Targeted therapies have improved RCC treatment outcomes.
  • Lower urinary tract symptoms (LUTS) are prevalent in aging male populations.

Purpose of the Study:

  • To investigate the impact of targeted drug therapy on LUTS in elderly men with RCC.
  • To identify risk factors associated with LUTS development and progression during targeted therapy.

Main Methods:

  • Retrospective analysis of 47 elderly male patients (≥60 years) with pathologically diagnosed RCC.
  • Evaluation of prostate volume, International Prostate Symptom Score (IPSS), and physical fitness before and after targeted therapy.
  • Logistic regression analysis to determine risk factors for LUTS deterioration.

Main Results:

  • A significant correlation was observed between advanced age and worsening LUTS.
  • Prolonged targeted drug treatment duration (average 13.7 months) was associated with increased occurrence and severity of LUTS.
  • Age and medication duration were identified as independent risk factors for LUTS deterioration.

Conclusions:

  • The use of anti-vascular targeting drugs in elderly men with RCC may promote LUTS as a side effect.
  • Clinicians should monitor for LUTS in elderly male patients undergoing targeted therapy.
  • Further research is warranted to explore the mechanisms and management of therapy-induced LUTS.
Keywords:
BPHLUTSRCCaging maletargeted therapy

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