Recent advances on Hippo-YAP pathway in skin diseases

Area of Science:

• Dermatology
• Molecular Biology
• Cell Signaling

Background:

• The Hippo-YAP pathway is a crucial regulator of cellular processes like proliferation and inflammation.
• Emerging evidence implicates this pathway in the development and progression of numerous skin disorders.

Purpose of the Study:

• To review recent advancements concerning the Hippo-YAP pathway in various skin diseases.
• To explore its mechanisms in skin tumors, inflammatory conditions, aging, wound healing, and development.
• To identify challenges, knowledge gaps, and potential therapeutic strategies.

Main Methods:

• Comprehensive literature review of studies on the Hippo-YAP pathway in skin biology and disease.
• Analysis of regulatory mechanisms across different dermatological contexts.
• Synthesis of current research to propose future directions.

Main Results:

• The Hippo-YAP pathway plays a multifaceted role in skin homeostasis and pathology.
• Dysregulation is observed in skin tumors, inflammatory diseases, aging, and impaired wound healing.
• The pathway's involvement spans from embryonic development to adult tissue maintenance.

Conclusions:

• Targeting the Hippo-YAP pathway presents promising therapeutic potential for skin diseases.
• Further research is needed to address study heterogeneity, experimental model variations, and clinical evidence gaps.
• Standardized, clinically focused research is essential for advancing treatment outcomes.