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Updated: Jan 20, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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A case of a digitate injection site reaction from subcutaneous bortezomib in a patient with myeloma

Rachel Creighton1, Tamryn Eglington2, Luke Y C Chen3,4

  • 1Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.

SAGE Open Medical Case Reports
|January 19, 2026
PubMed

The proteasome inhibitor bortezomib is widely used in the treatment of multiple myeloma. While peripheral neuropathy and gastrointestinal effects are well-documented adverse reactions to bortezomib administration, cutaneous side effects in patients with multiple myeloma are less commonly reported. We present a patient with IgG kappa multiple myeloma who developed a spider-like and digitate eruption at the site of subcutaneous bortezomib injection. This report expands the spectrum of bortezomib-associated dermatologic toxicity and emphasizes the importance of clinician awareness for prompt diagnosis and management.

Keywords:
bortezomibcutaneous toxicitydrug reaction

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