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Updated: Jan 20, 2026

Behavioral Tests to Assess Executive Functions in Children with ASD

Behavioral Tests to Assess Executive Functions in Children with ASD

Published on: April 30, 2023

Progress in exercise interventions for autism spectrum disorder: exploring underlying mechanisms.

Chaofan Wang¹, Yuanxiang Zhang², Jimiao Zhu³

¹Minjiang University,Public Physical Education, Fuzhou, China.

Frontiers in Psychiatry

|January 19, 2026

Summary

Physical activity positively impacts autism spectrum disorder (ASD) by modulating neuronal factors, glial cells, and gut microbiota. Exercise interventions can alleviate core ASD symptoms and improve overall health.

Keywords:

ASD exercise intervention mechanism review

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Autism Spectrum Disorder

Autism Spectrum Disorder

Area of Science:

Neuroscience
Autism Spectrum Disorder Research
Exercise Physiology

Background:

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by core symptoms affecting social interaction and communication.
Physical activity is increasingly recognized for its therapeutic potential in managing ASD-related challenges.
Understanding the underlying mechanisms of physical activity interventions is crucial for optimizing treatment strategies.

Purpose of the Study:

To synthesize current literature on the mechanisms by which physical activity influences ASD.
To identify the key biological pathways modulated by exercise in individuals with ASD.
To review the effects of physical activity on behavioral and physiological outcomes in ASD.

Main Methods:

A comprehensive literature review and synthesis approach was employed.
Relevant studies investigating physical activity interventions and their effects on ASD were systematically identified and analyzed.
Data regarding neuronal, glial, and gut microbiota changes, as well as behavioral and health outcomes, were integrated.

Main Results:

Physical activity interventions primarily modulate ASD through effects on neuronal factors (e.g., brain-derived neurotrophic factor, neurotransmitters), glial cells, and gut microbiota.
Exercise demonstrably alleviates ASD core symptoms, including stereotypical behaviors and anxiety.
Physical activity also contributes to managing comorbidities such as obesity and cardiovascular disease, and enhances social communication skills.

Conclusions:

Physical activity offers a promising non-pharmacological approach for managing ASD symptoms and improving quality of life.
Targeting neuronal, glial, and gut microbiota pathways through exercise presents a multifaceted strategy for ASD intervention.
Further research is warranted to optimize exercise protocols for individuals with ASD.