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Updated: Jan 20, 2026
Author Spotlight: A Rapid, Microwave-Assisted Hydrothermal Synthesis Of Nickel Hydroxide Nanosheets
Published on: August 18, 2023
Synthesis and structure of N-(perfluoro-phen-yl)isonicotinamide
Arindam Saha1, Garry S Hanan1, Mihaela Cibian2
1Département de chimie, Université de Montréal, Complexe des sciences, 1375, Avenue Thérèse-Lavoie-Roux, Montréal, Québec, H2V 0B3, Canada.
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The title compound [systematic name: N-(2,3,4,5,6-penta-fluoro-phen-yl)pyridine-4-carboxamide], C12H5F5N2O, crystallizes with two independent mol-ecules (A and B) in the asymmetric unit in space group P1. The mol-ecules adopt a conformation where the planes of the penta-fluoro-phenyl and pyridyl rings have twist angles of 5.3 (1) and 14.5 (1)°. In the crystal, the mol-ecules are connected by N-H⋯N hydrogen bonds between the amide H atom and the pyridyl nitro-gen atom of an adjacent mol-ecule to generate [110] chains of alternating A and B mol-ecules. The packing is consolidated by C-H⋯π inter-actions, π-π stacking and C-H⋯O inter-actions and a short F⋯F contact of 2.7270 (13) Å occurs. The structures of related isonicotinamides are surveyed.
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