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Updated: Jan 20, 2026

An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering
Published on: July 6, 2019
Practical aspects of teaching a graduate-level small-mol-ecule chemical crystallography course
1Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison, WI 53706, USA.
Abstract:
We present the practical curriculum of the graduate Chemical Crystallography course in the Department of Chemistry of the University of Wisconsin-Madison, outlining our favorite resources, texts, and software. The course relies on collaborative in-class student assignments that build up a knowledge base of fundamental crystallography and 37 hands-on structure solution and refinement exercises spanning structures of varying difficulty. Students begin solving and refining structures early in the course, following a 'do first, understand second' philosophy. The strong focus on data inter-pretation ensures that students gain the practical skills necessary for independent structural investigation and critical evaluation of the crystallographic literature.
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