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Mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD) with metabolic dysfunction, hepatic gene expression changes, and liver histopathological alterations that resemble human MASLD, including fibrosis that progresses to advanced fibrosis stage 3. This model can be used in studies of MASLD pathophysiology and in pre-clinical studies of new therapies.
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Related Experiment Video

Updated: Jan 20, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
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Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis

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MAM and LDL Receptor Class A Domain Containing 1 Deficiency Aggravates Hepatic Fibrosis in Diet-Induced Metabolic

Jashdeep Bhattacharjee1, Linda X Wang1, Brianna Meneses1

  • 1Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Los Angeles, California.

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No abstract available in PubMed .

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