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Updated: Jan 20, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Efavirenz-Induced Hepatitis Mimicking Autoimmune Hepatitis: A Case Report
Adibul H Chowdhury1, Dristy Chowdhury2, Israt Jahan3
1Internal Medicine, University Hospital of Coventry and Warwickshire NHS Foundation Trust, Coventry, GBR.
Delayed liver injury from efavirenz (a non-nucleoside reverse transcriptase inhibitor) can mimic autoimmune hepatitis. Prompt drug withdrawal led to recovery, highlighting the importance of considering late antiretroviral therapy toxicity.
Area of Science:
- Hepatology
- Infectious Diseases
- Pharmacology
Background:
- Efavirenz is a common non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV treatment.
- Hepatotoxicity from NNRTIs usually occurs early, but delayed reactions are rare.
- Distinguishing drug-induced liver injury from autoimmune hepatitis can be challenging.
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