Related Concept Videos

A Reverse Genetic Approach to Test Functional Redundancy During Embryogenesis06:59

A Reverse Genetic Approach to Test Functional Redundancy During Embryogenesis

Gene function can be obscured in loss-of-function experiments if there is compensation by another gene. The zebrafish model provides a relatively high-throughput means to reveal such functional redundancy in living...
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Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain03:26

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

The protocol outlines the surgical procedure for the treatment of postamputation pain using Targeted Muscle Reinnervation (TMR). TMR will be compared with two other surgical techniques, specifically Regenerative Peripheral Nerve Interface (RPNI) and neuroma excision, followed by immediate burying within muscle under the context of an international, randomized controlled...
3.5K
Testing Sensory Nerve Function in a Surgically Denervated Mouse Model04:26

Testing Sensory Nerve Function in a Surgically Denervated Mouse Model

This video demonstrates testing sensory nerve function in a mouse model by surgically denervating one side and leaving the other as a control. The response to mechanical stimulation confirms the role of sensory...
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Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice10:50

Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice

The tibial nerve transection model is a well-tolerated, validated, and reproducible model of skeletal muscle atrophy. The model surgical protocol is described and demonstrated in C57Black6 mice.
25.3K
Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

This article includes detailed protocols for genetic labeling of mouse skin, surgical denervation, skin biopsy and visualizing labeled epithelia by whole-mount β-galactosidase staining. These methods can be used to test the requirement for nerves in mouse models of normal and pathological...
10.5K
Real-Time Imaging of CCL5-Induced Migration of Periosteal Skeletal Stem Cells in Mice06:10

Real-Time Imaging of CCL5-Induced Migration of Periosteal Skeletal Stem Cells in Mice

This protocol describes the detection of CCL5-mediated periosteal skeletal stem cell migration in real-time using live animal intravital...
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