Related Experiment Video
Updated: Jan 20, 2026

Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Dementia, Advance Directives, and Second-Order Volitions
1York University, Toronto, Ontario, Canada.
Advance directives from a pre-dementia self should generally guide care over conflicting post-dementia wishes, especially when capacity for self-reflection is lost. This upholds prior values in dementia care.
Area of Science:
- Bioethics
- Philosophy of Mind
- Neuroethics
Background:
- Advance directives are crucial for patient autonomy.
- Dementia poses challenges to respecting patient autonomy due to evolving preferences.
- The philosophical basis for prioritizing past versus present wishes in diminished capacity is debated.
Purpose of the Study:
- To explore the authority of advance directives when dementia patients express conflicting desires.
- To apply Harry Frankfurt's theory of second-order volitions to resolve conflicts between pre-dementia and post-dementia selves.
- To establish a framework for prioritizing patient preferences in end-of-life care decisions for individuals with dementia.
Main Methods:
- Philosophical analysis using Harry Frankfurt's concept of second-order volitions.
- Argumentative reasoning to weigh the preferences of the 'then-self' against the 'now-self'.
- Case analysis focusing on scenarios where dementia impacts the capacity for volitional judgment.
Main Results:
- The pre-dementia self's preferences ('then-self') should typically take precedence over the post-dementia self's ('now-self').
- This prioritization is particularly relevant when the 'now-self' lacks the capacity for second-order volitions.
- The ability to meaningfully repudiate prior values is a key factor in assessing the weight of current preferences.
Conclusions:
- Upholding advance directives from the pre-dementia self respects enduring values and commitments.
- This approach offers a principled way to manage conflicting desires in dementia care.
- The capacity for second-order volitions is central to determining the authority of current preferences in advance care planning.
Related Concept Videos
09:17Using Retinal Imaging to Study Dementia
Dementia
The progression of dementia is generally gradual....
11:12Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
07:41Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
06:23The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
05:12A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
