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Updated: Jan 20, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
Published on: November 2, 2011
Protein Amyloid and Synthetic Polymer Self-Assemblies: Similar Challenges for Their Preparation Associated with
Barbara Lonetti1, Steve Bourgault2, Joseph Chamieh3
1Université de Toulouse, CNRS, Laboratoire Softmat, UMR 5623, 118 Rte de Narbonne,Toulouse Cedex 31062, France.
None:
This publication constitutes a comparison of two apparently different communities, namely, synthetic polymer self-assemblies and amyloid aggregates, to cross-fertilize each other. The starting point is shared recognized issues in the reproducibility of the fabrication of the aggregates for each community. Based on this, this publication compares the underlying mechanistic principles of self-assembly, the methods for the preparation of assemblies, and the techniques used for their characterization. This highlights some common practices, while also revealing notable differences. Interestingly, some techniques may be used by both communities but with different perspectives and aims, whereas others are preferably employed by one community. The article finally suggests possible cross-advice for each one.
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