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Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
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Harnessing Cuproptosis resistance to advance cancer therapeutics

Zi-Zhan Li1, Tian-Fu Wu2, Zhi-Jun Sun3

  • 1The State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, China.

Apoptosis : an International Journal on Programmed Cell Death
|January 19, 2026
PubMed

Insights

Cuproptosis, a novel cancer cell death method, shows promise but faces resistance. Nanomedicine strategies are being developed to enhance cuproptosis sensitivity and overcome resistance for better cancer treatment outcomes.

Area of Science:

  • Biochemistry
  • Immunology
  • Oncology

Background:

  • Cuproptosis is a newly discovered form of programmed cell death with anticancer properties.
  • Current cuproptosis-based cancer therapies are largely preclinical, with limited clinical success due to resistance.
  • Understanding and overcoming cancer cell resistance to cuproptosis is critical for therapeutic advancement.

Purpose of the Study:

  • To review cellular copper homeostasis and its regulation in cancer.
  • To compare cuproptosis with other forms of immunogenic cell death.
  • To discuss strategies for enhancing cuproptosis sensitivity and overcoming resistance.

Main Methods:

  • Literature review of cellular copper metabolism and cuproptosis.
  • Analysis of resistance mechanisms in cancer cells.
  • Exploration of nanomedicine approaches for targeted therapy.

Main Results:

  • Cuproptosis sensitivity is influenced by cellular copper levels and metabolic state.
  • Cancer cells employ metabolic reprogramming and signaling pathway alterations to resist cuproptosis.
  • Nanomedicine offers potential to target metabolic vulnerabilities and reverse resistance.

Conclusions:

  • Cuproptosis holds significant anticancer potential, but overcoming resistance is key.
  • Nanomedicine strategies targeting metabolic vulnerabilities show promise for enhancing cuproptosis.
  • Modulating cuproptosis may offer broader therapeutic applications beyond oncology.
Keywords:
BiomaterialsCancer immunotherapyCuproptosisResistanceSensitivity

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