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Updated: Jan 21, 2026

Multi-analyte Biochip MAB Based on All-solid-state Ion-selective Electrodes ASSISE for Physiological Research
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A Multi-Ion Super-Nernstian Sensing Platform Based on MoS2 Near-Sensor Amplifiers.

Haojie Zhao1, Jiawen Yan1, Yixuan Zou1

  • 1State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing 100084, China.

ACS Applied Materials & Interfaces
|January 19, 2026
PubMed
Summary

This study introduces a novel super-Nernstian sensing platform using a molybdenum disulfide (MoS2) inverter array for enhanced multi-ion detection in biofluids. The technology promises improved sensitivity and stability for point-of-care diagnostics.

Keywords:
MoS2invertermulti-ion sensornear-sensor amplificationsuper-Nernstian

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Accurate measurement of multiple ions in biofluids is vital for healthcare.
  • Ion-sensitive field-effect transistors offer label-free, low-cost sensing but are limited by the Nernst limit.
  • Existing methods to overcome the Nernst limit lack integration or stability.

Purpose of the Study:

  • To develop a multi-ion super-Nernstian sensing platform overcoming the Nernst limit.
  • To enhance sensitivity and stability in ion detection using near-sensor amplification.
  • To enable advanced point-of-care diagnostics through improved ion measurement.

Main Methods:

  • Coupling a molybdenum disulfide (MoS2) inverter array with a multi-ion sensor chip in an extended-gate configuration.
  • Utilizing the high gain and stability of MoS2 inverters, facilitated by graphene and hexagonal boron nitride (h-BN).
  • Demonstrating in situ amplification for super-Nernstian ion detection.

Main Results:

  • Achieved super-Nernstian detection of pH, Na+, K+, and Ca2+ in biofluid ranges.
  • Demonstrated stable long-term responses and selectivity.
  • Validated platform practicality through artificial sweat analysis.

Conclusions:

  • The proposed MoS2-based inverter amplifier enables super-Nernstian ion sensing, surpassing the Nernst limit.
  • The platform offers high sensitivity, stability, and practicality for biofluid analysis.
  • This approach is promising for point-of-care diagnostics and near-sensor computing applications.