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Life's Essential 8 and the Risk of Overall and Specific-Site Cancer Types: A Large-Scale Prospective Cohort Study.
Li Deng1,2,3,4, Xiao-Meng Hao5, Zhe Shu6
1Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Cancer Medicine
|January 19, 2026
Summary
Higher adherence to Life's Essential 8 (LE8) significantly lowers overall cancer incidence and risk for specific cancer types. This framework shows promise for cancer prevention strategies.
Area of Science:
- Cardiovascular Health and Oncology
- Public Health and Epidemiology
Background:
- The Life's Essential 8 (LE8) framework, established for cardiovascular disease prevention, has potential implications for cancer risk, though its direct association with cancer incidence requires further study.
- Individual LE8 components may differentially influence cancer risk across various organ systems, necessitating detailed investigation.
Purpose of the Study:
- To investigate the association between adherence to the Life's Essential 8 (LE8) framework and the incidence of various cancer types.
- To explore the impact of individual LE8 components on cancer risk within a large prospective cohort.
Main Methods:
- A prospective cohort study of 94,239 participants from the Kailuan Study in China was conducted.
- LE8 scores were computed using lifestyle and biomarker data; cancer incidence was tracked until December 31, 2022.
- Cox proportional hazards and competing risk models were employed to analyze the relationship between LE8 adherence and cancer risk, adjusting for confounders.
Main Results:
- Higher LE8 adherence was associated with a significant reduction in overall cancer incidence, with ideal adherence showing a 26% decrease (HR=0.74).
- LE8 improvements correlated with reduced risks for lung (9%), breast (12%), kidney (18%), colorectal (7%), and endometrial (31%) cancers.
- Ideal blood pressure and non-smoking were protective, while ideal body weight was associated with increased risk; non-smoking specifically reduced lung and kidney cancer risk.
Conclusions:
- The Life's Essential 8 (LE8) framework is a valuable tool for cancer prevention, demonstrating a clear link between higher adherence and lower cancer incidence.
- Integrating the LE8 framework into public health initiatives and clinical practice could enhance cancer prevention efforts.
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