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Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
Published on: February 10, 2023
[Assessment of Locally Advanced Colorectal Cancer Cases Successfully Resected after Chemotherapy]
Hajime Yokomizo1, Sachiyo Okayama, Shunsuke Iwamoto
1Dept. of Surgery, Tokyo Women's Medical University Adachi Medical Center.
None:
The purpose of this study was to clarify the prognostic factors of locally advanced colorectal cancer cases without distant metastasis successfully resected after chemotherapy.We investigated the association between prognosis and clinicopathological factors in 25 cases of locally advanced colorectal cancer without distance metastasis that underwent curative resection after chemotherapy between 2008 and 2021.The association between clinicopathological factors and DFS showed no difference in the use of molecular targeted drugs, response criteria, depth of tumor invasion, lymph node metastasis, but the prognosis was better in cases with a histological response Grade 1b or higher(p=0.039)and the cases underwent postoperative adjuvant chemotherapy(p=0.021), and both of these factors were extracted as independent prognostic factors for DFS in multivariate analysis.These results suggest that the histological response grade may be a useful prognostic factor in locally advanced colorectal cancer cases without distant metastasis successfully resected after chemotherapy.
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