Related Experiment Video
Updated: Jan 21, 2026

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises
Published on: January 18, 2011
sRACIPE 2.0: a systems biology circuit modeling toolkit for random circuit perturbation
Aidan Tillman1,2, Daniel Ramirez1,2, Mingyang Lu1,2
1Department of Bioengineering, Northeastern University, Boston, MA 02115, United States.
Summary:
The Random Circuit Perturbation (RACIPE) algorithm enables the exploration of the dynamical behaviors of gene regulatory circuits (GRCs) by simulating an ensemble of differential equation models via randomization of kinetic parameters. Here, we release sRACIPE 2.0, a major update to the R/Bioconductor package, as a unified platform for modeling GRCs with diverse interaction types using both deterministic and stochastic simulations. The update also introduces new features for modeling perturbation, extrinsic signaling and time-corrected noise, and a new diagnostic tool to ensure proper simulations. We hope that this release will serve as a versatile modeling toolkit for the systems biology community.
Availability And Implementation:
The package is available on GitHub at https://github.com/lusystemsbio/sRACIPE under the MIT license. It is also available on Bioconductor at https://www.bioconductor.org/packages/release/bioc/html/sRACIPE.html.
Related Concept Videos
Second-Order Circuits
Input signals typically originate from voltage or current sources, with the output often representing voltage across the capacitor and/or current through the inductor. For example, in...
First-Order Circuits
One common example of a first-order circuit is the RC (resistor-capacitor) circuit. These circuits are used in relaxation oscillators such as neon lamp oscillator circuits. When voltage is...
The Y-to-Y Circuit
LC Circuits
Three-Phase Circuits
Clipper Circuit
The operation of a clipper circuit can be exemplified by analyzing a dual-clipper configuration setup that integrates two ideal diodes, each paired with a biasing...

