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Hand Grip Strength Predicts Cognitive Decline in Subjective Cognitive Decline: 2-Year Follow-up Results
Eun Ye Lim1, Yun Jeong Hong2, Jee Hyang Jeong3
1Department of Neurology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Journal of Korean Medical Science
|January 20, 2026
Summary
Reduced hand grip strength (HGS) in older adults with subjective cognitive decline is linked to amyloid pathology and cognitive decline, particularly in visuospatial and executive functions.
Area of Science:
- Neurology
- Gerontology
- Biomarkers
Background:
- Hand grip strength (HGS) is a potential marker for cognitive decline.
- Its relationship with specific cognitive domains and amyloid pathology needs further clarification.
Purpose of the Study:
- To investigate the association between HGS and domain-specific cognitive changes in older adults with subjective cognitive decline (SCD).
- To explore the role of amyloid pathology in this relationship.
Main Methods:
- A longitudinal study of 107 older adults with SCD over 24 months.
- Categorization based on hand grip strength (HGS) weakness using Asian Working Group of Sarcopenia criteria.
- Logistic regression and repeated measures ANOVA to analyze cognitive changes and HGS association, adjusting for covariates and amyloid positivity.
Main Results:
- Individuals with HGS weakness showed higher amyloid positron emission tomography (PET) positivity (47.1% vs. 18.9%).
- HGS weakness correlated with poorer baseline and declining visuospatial and executive functions.
- HGS weakness predicted decline in visuospatial function and verbal memory, though significance decreased after adjusting for amyloid positivity.
Conclusions:
- HGS weakness is linked to cognitive decline in visuospatial and executive domains in older adults with SCD.
- It may indicate early amyloid-related neurodegeneration.
- HGS assessment is a practical tool for identifying at-risk individuals, especially when amyloid PET is unavailable.
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