Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lumber Defects01:23

Lumber Defects

486
Lumber defects, which can affect both the appearance and structural integrity of wood, include a variety of growth and manufacturing flaws. Growth defects such as knots and knotholes occur where branches were once attached to the tree trunk, with knotholes forming when these knots fall out. Other natural defects include decay and insect damage, which compromise the wood's strength and durability.
Shakes are minor fractures that run along or across the wood's annual rings, while wane is...
486
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

14.3K
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
14.3K
Gene Therapy00:59

Gene Therapy

27.4K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
Layers of the Epidermis01:21

Layers of the Epidermis

7.9K
The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
7.9K
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

5.7K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.7K
Two-Dimensional (2D) NMR: Overview01:12

Two-Dimensional (2D) NMR: Overview

1.5K
The 1D NMR spectrum of large and complex molecules like natural products has complicated splitting patterns and overlapping signals, which can be easily interpreted using 2-dimensional (2D) NMR. Unlike 1D NMR, 2D NMR has two frequency axes that provide the coupling information between the nucleus A and nucleus B in a molecule. The process from which 2D spectra are obtained has four steps.
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse....
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Self-Immunoregulatory Nanosensitizer for Sonodynamic Cancer Therapy.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

A Self-Cascading Immunomodulatory Hydrogel for Remodeling Infected Diabetic Wounds.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Synergistic Chemoimmunotherapy of Hepatocellular Carcinoma via ROS-Responsive Carrier-Free Prodrug Nanoparticles.

Nano letters·2026
Same author

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Multifunctional ruthenium-based complexes for chronic wound therapy: from ligand engineering to intelligent microenvironment remodeling.

Nanoscale·2026
Same author

A Near-Infrared Off-On Fluorescent Probe for Sensitive and Specific Imaging of Fibroblast Activation Protein-α Activity in Pancreatic Cancer.

Luminescence : the journal of biological and chemical luminescence·2026

Related Experiment Video

Updated: Jan 21, 2026

Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System
09:07

Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System

Published on: February 10, 2023

3.2K

Defect-Rich 2D Layered Double Hydroxides Enhance Sonodynamic Antibacterial Therapy.

Qian Liu1,2, Yu Yang3, Rui Zhao1,2

  • 1Zhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 20, 2026
PubMed
Summary

Defect-rich layered double hydroxide (LDH) nanosheets were engineered to enhance sonodynamic therapy (SDT) for antibiotic-resistant infections. These novel materials significantly boost reactive oxygen species (ROS) production under ultrasound, improving antibacterial efficacy.

Keywords:
LDHsSDTantibacterialdefect engineering

More Related Videos

Studying Cavitation Enhanced Therapy
07:36

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

5.7K
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.7K

Related Experiment Videos

Last Updated: Jan 21, 2026

Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System
09:07

Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System

Published on: February 10, 2023

3.2K
Studying Cavitation Enhanced Therapy
07:36

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

5.7K
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.7K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Sonodynamic therapy (SDT) offers a non-invasive approach to combat antibiotic-resistant bacteria.
  • Current sonosensitizers often exhibit limited reactive oxygen species (ROS) generation under ultrasound (US) irradiation.
  • Layered double hydroxides (LDHs) possess tunable properties and good biocompatibility, but their application in SDT for antibacterial purposes is underexplored.

Purpose of the Study:

  • To develop a novel defect-rich 2D layered double hydroxide (DR-LDH) material for enhanced sonodynamic antibacterial therapy.
  • To investigate the impact of defect engineering and phase transition on the electronic structure and ROS generation of ZnCuW-LDH nanosheets.
  • To validate the in vitro and in vivo antibacterial efficacy of the engineered DR-ZnCuW-LDH nanosheets under ultrasound irradiation.

Main Methods:

  • Fabrication of defect-rich 2D DR-ZnCuW-LDH nanosheets using a facile acid-etching method at ambient conditions.
  • Characterization of the phase transition, defect formation (oxygen vacancies), and bandgap narrowing (from 3.29 to 1.80 eV) using advanced analytical techniques.
  • Evaluation of ROS generation enhancement under ultrasound irradiation compared to pristine ZnCuW-LDH.
  • In vitro and in vivo antibacterial efficacy testing of DR-ZnCuW-LDH nanosheets under US exposure.

Main Results:

  • The acid-etching method successfully produced defect-rich DR-ZnCuW-LDH nanosheets with a crystalline-to-polycrystalline phase transition.
  • Engineered nanosheets exhibited significantly narrowed bandgaps and improved electron-hole separation due to introduced defects and oxygen vacancies.
  • DR-ZnCuW-LDH demonstrated a fourfold increase in ROS generation under US irradiation compared to pristine LDH.
  • Both in vitro and in vivo studies confirmed the exceptional antibacterial efficacy of DR-ZnCuW-LDH under SDT.

Conclusions:

  • Defect engineering via acid-etching is an effective strategy to enhance the sonodynamic performance of LDHs.
  • The developed DR-ZnCuW-LDH nanosheets show great promise as efficient inorganic sonosensitizers for combating antibiotic-resistant infections.
  • This work establishes a versatile platform for advanced sonodynamic antibacterial applications.