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Iridium-Catalyzed Stereoselective α-Alkylation of α-Hydroxy Ketones with Minimally Polarized Alkenes
Yihong Wang1, Fenglin Hong1, Craig M Robertson1
1Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom.
Abstract:
Cationic Ir(I)-complexes modified with homochiral diphosphines promote the α-C-H addition of α-hydroxy ketones to styrenes or alkyl olefins. These processes are predicated on the hydroxyl-directed formation of an Ir-enolate. Inter- and intramolecular processes are feasible, with the latter offering stereocontrolled access to carbocycles bearing two new stereocenters. The intramolecular processes constitute rare examples of alkene-based Conia-ene reactions that are enantio- and diastereoselective.
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