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Updated: Jan 22, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Icotrokinra: A Promising Oral IL-23 Receptor Inhibitor for Moderate-to-Severe Plaque Psoriasis

Fyona Okundia1, Muna Shakhashiro1, Stephen K. Tyring1,2

  • 1Center for Clinical Studies, Houston, TX, USA.

Skin Therapy Letter
|January 20, 2026
PubMed

Biologics have emerged in recent years as relatively safe and effective options for managing plaque psoriasis, however, a subset of patients remain reluctant to initiate biologic therapy. Icotrokinra is a novel, first-in-class oral peptide that targets the interleukin-23 receptor and has demonstrated a favorable safety and efficacy profile comparable to that of injectable biologics in individuals aged 12 years and older. This review summarizes the clinical trial data regarding the safety and efficacy of icotrokinra.

Keywords:
IL-23 receptorbiologicsclinical trialsimmune mediated inflammatory diseaseoral peptidepsoriasis

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