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Updated: Jan 22, 2026

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Cardiomyocyte mechanical contraction sensitivity-enhanced biosensing for precise drug evaluation.

Tao Liang1, Zhekun Jia1, Chengyun Wang1

  • 1Laboratory Medicine Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China; Department of Chemistry, Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.

Biosensors & Bioelectronics
|January 20, 2026
PubMed
Summary

A novel biosensing platform using size-regulable impedance sensors offers a cost-effective and efficient method for preclinical cardiovascular drug screening and cardiac safety assessment.

Keywords:
Cardiomyocyte modelDrug evaluationMechanical contractilityMulti-channel detection platformSize-regulable impedance sensor (SRIS)

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Area of Science:

  • Biomedical Engineering
  • Cardiology
  • Pharmacology

Background:

  • Cardiovascular diseases are a leading cause of global mortality, necessitating robust preclinical drug screening and cardiac safety evaluations.
  • Existing in vitro cardiomyocyte models for drug testing face limitations such as phototoxicity, low frame rates, and high fabrication costs.

Purpose of the Study:

  • To develop and validate a novel, cost-effective, and efficient mechanical contraction biosensing platform for cardiomyocyte drug evaluation.
  • To assess the platform's capability in long-term cellular viability and contraction monitoring for pharmacological assessment.

Main Methods:

  • Introduction of a multi-channel size-regulable impedance sensor (SRIS) platform with a custom detection system.
  • Optimization of electrode sizes and driving frequencies for SRIS sensors.
  • Application of SRIS for long-term assessment of cardiomyocyte contraction dynamics and drug effects.

Main Results:

  • The SRIS platform demonstrated straightforward and efficient fabrication, reducing economic and temporal costs.
  • Systematic determination of optimal driving frequencies for three distinct electrode sizes.
  • Successful capture of cardiomyocyte contraction property changes induced by various cardiac drugs (agonist, blocker, inhibitor) in a dose-dependent manner.

Conclusions:

  • The facilely fabricated, cost-effective, and size-regulable SRIS platform provides precise pharmacological assessment of cardiac drugs.
  • This biosensing platform holds significant potential for advancing cardiology and pharmacology research in drug evaluation and cardiac safety.