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Updated: Jan 22, 2026

Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
[Dementia in the Lewy Body Disease Spectrum]
1Department of Behavioral Neurology and Neuropsychiatry, The University of Osaka.
Abstract:
The timing of dementia onset in patients with Parkinson's disease varies significantly. Predictors of the early development of dementia include postural instability, gait disturbance, REM sleep behavior disorder, and visuo-spatial impairment. The main neuropathological basis of dementia in Parkinson's disease involves the co-occurrence of α-synuclein pathology in the cerebral cortex and Alzheimer's disease co-pathology. Cholinergic system degeneration significantly affects symptom expression, making cholinesterase inhibitors effective for alleviating visual hallucinations and cognitive deficits.
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