Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

5.4K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
5.4K
Continuing Care01:25

Continuing Care

1.9K
Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
1.9K
Continuity Equation01:28

Continuity Equation

3.3K
The continuity equation asserts that the mass flow rate must remain constant for a steady flow of an incompressible fluid within a confined system. This principle applies to systems where fluid passes through varying cross-sectional areas, such as nozzles, syringes, and pipes.
The mass flow rate is expressed as:
3.3K
Continuity Equation01:20

Continuity Equation

1.5K
The total amount of current flowing per unit cross-sectional area is called the current density. Hence, the current passing through a cross-sectional area can be written as the surface integral of the current density.
1.5K
Equation of Continuity01:12

Equation of Continuity

10.5K
Fluid motion is represented by either velocity vectors or streamlines. The volume of a fluid flowing past a given location through an area during a period of time is called the flow rate Q, or more precisely, the volume flow rate. Flow rate and velocity are related—for instance, a river has a greater flow rate if the velocity of the water in it is greater. However, the flow rate also depends on the size and shape of the river. The relationship between flow rate (Q) and average speed (v)...
10.5K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

214
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
214

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transient Neonatal Cyanosis Exacerbated by Inhaled Nitric Oxide.

AJP reports·2026
Same author

Biological sex modulates lung injury severity in adolescent mice exposed to short-term aerosolized vitamin E acetate.

Physiological reports·2025
Same author

Unmasking the Hidden Risk of Systemic Toxicity from Topical Salicylates.

The western journal of emergency medicine·2025
Same author

Characteristics and Trends in Child Cannabis Exposures During Legalization in California.

American journal of preventive medicine·2025
Same author

A ten-year retrospective California Poison Control System experience with water bead exposures: a growing problem.

Clinical toxicology (Philadelphia, Pa.)·2025
Same author

Oxidative stress, burnout, National Institutes of Health, work relative value units, and Medicaid: Need for an emergency transfusion.

Pediatric research·2025
Same journal

Downward Trends in Neonatal Hepatitis B Vaccine Uptake: 2021 to 2025.

Hospital pediatrics·2026
Same journal

Use of Stigmatizing Language in Pediatric Clinician Notes.

Hospital pediatrics·2026
Same journal

Lead Locally, Impact Nationally: Roles and Responsibilities for Site PI in PHM Research.

Hospital pediatrics·2026
Same journal

Trends, Outcomes, and Resource Use of Pediatric Tracheostomy in Alberta: A Cohort Study.

Hospital pediatrics·2026
Same journal

Too Complex to Treat? Equity in Access to Inpatient Pediatric Pain Rehabilitation.

Hospital pediatrics·2026
Same journal

Caregiver Perspectives on Preventing Future Hospitalizations for Children With Medical Complexity.

Hospital pediatrics·2026
See all related articles

Related Experiment Video

Updated: Jan 22, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.4K

Pediatric Intravenous Acetaminophen Overdoses: A Continuing Iatrogenic Problem.

Alexandra Moseanko1, Cherie Ginwalla1, Melissa Eidman1

  • 1Department of Pediatrics, University of California, Davis, Davis, California.

Hospital Pediatrics
|January 20, 2026
PubMed
Summary
This summary is machine-generated.

Pediatric intravenous acetaminophen overdoses still occur, posing risks in acute care. Identifying toxicity and the need for N-acetylcysteine (NAC) treatment remains difficult, highlighting the need for improved prevention strategies.

More Related Videos

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

11.0K
Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

1.3K

Related Experiment Videos

Last Updated: Jan 22, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.4K
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

11.0K
Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

1.3K

Area of Science:

  • Pediatric pharmacology
  • Medication safety
  • Toxicology

Background:

  • Intravenous (IV) acetaminophen is widely used in pediatric care.
  • Iatrogenic medication errors, including overdosing, are a significant concern in healthcare settings.

Purpose of the Study:

  • To investigate the continued occurrence of iatrogenic overdosing with intravenous acetaminophen in children.
  • To analyze the characteristics and outcomes of pediatric IV acetaminophen dosing errors.

Main Methods:

  • A retrospective study analyzed 14 years (2011-2024) of California Poison Control System calls related to pediatric IV acetaminophen dosing errors.
  • Data included patient age, dose administered, location within the hospital, N-acetylcysteine (NAC) use, and outcomes.
  • Descriptive statistics were employed to summarize the findings.

Main Results:

  • A total of 45 pediatric cases of IV acetaminophen overdosing were identified.
  • Doses ranged significantly, with mean doses of 45.5 ± 36.7 mg/kg.
  • Adverse events occurred across various hospital locations, including operative areas, inpatient units, ICUs, and emergency departments. No long-term adverse effects were observed.

Conclusions:

  • Iatrogenic overdoses of IV acetaminophen in children are infrequent but continue to occur in acute care.
  • Assessing potential toxicity and the necessity of NAC treatment presents challenges.
  • Enhanced strategies are required to prevent these serious medication errors.