Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

1.4K
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.4K
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

3.0K
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
3.0K
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

2.0K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
2.0K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

4.6K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
4.6K
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

8.1K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
8.1K
Hypoxia01:23

Hypoxia

2.5K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resuscitation of neonatal critical care: a call for identity and course correction.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Oxygen Saturation Target Achievement in Preterm Infants <32 Weeks' Gestation with 9<sup>th</sup> Edition NRP Guidelines: A Multicenter Observational Study in Latin America.

Research square·2026
Same author

Farewell to PGY-6? Addressing the realities of pediatric fellowship training.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Feeding Practices in Simple Gastroschisis: Insights into Practice Variation from a Multidisciplinary Survey.

Journal of pediatrics. Clinical practice·2026
Same author

Comparison of neonatal outcomes of term neonates with meconium-stained amniotic fluid before and after routine endotracheal suctioning strategy at birth.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

The impact of abortion bans on neonatal intensive care utilization.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same journal

Antenatal Testing Education: Assessing Health Education and Health Knowledge in a High-Risk Pregnant Population.

AJP reports·2026
Same journal

Cross-Sectional Survey of Obstetrical Providers' Knowledge, Attitudes, and Use of Noninvasive Prenatal Testing for 22q11.2 Deletion.

AJP reports·2026
Same journal

Obligate Funic Presentation: A Case Report of Velamentous Cord Insertion in a Normally Implanted Placenta.

AJP reports·2026
Same journal

Refractory Neonatal Apnea Revealing Congenital Central Hypoventilation Syndrome: Improved Outcome through Early Multidisciplinary Intervention.

AJP reports·2026
Same journal

Congenital Thrombocytosis, Hepatosplenomegaly, and Rash in a Term Neonate.

AJP reports·2026
Same journal

Concordant Open Neural Tube Defects in a Monochorionic Twin Pair of a Dichorionic-Triamniotic Triplet Gestation.

AJP reports·2026
See all related articles

Related Experiment Video

Updated: Mar 20, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
05:46

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

5.9K

Transient Neonatal Cyanosis Exacerbated by Inhaled Nitric Oxide.

Kaquanta Barlow1, Charles J Sadle1, Vidhi Jhaveri1

  • 1Department of Pediatrics, UC Davis Children's Hospital, Sacramento, California, United States.

AJP Reports
|March 19, 2026
PubMed
Summary
This summary is machine-generated.

Hereditary methemoglobinemia can cause newborn cyanosis, mimicking heart or lung issues. Early diagnosis and avoiding triggers like inhaled nitric oxide are crucial for management.

Area of Science:

  • Neonatal Medicine
  • Hematology
  • Genetics

Background:

  • Methemoglobinemia in newborns causes cyanosis and hypoxemia, often misdiagnosed as congenital heart disease or pulmonary hypertension.
Keywords:
Hb F-M-Osaka variantcyanosishereditary methemoglobinemiainhaled nitric oxidetransient neonatal cyanosis

More Related Videos

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

5.0K
How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children
07:27

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

Published on: August 19, 2020

12.8K

Related Experiment Videos

Last Updated: Mar 20, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
05:46

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

5.9K
Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

5.0K
How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children
07:27

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

Published on: August 19, 2020

12.8K
  • Persistent cyanosis with low oxygen saturation (SpO2) and normal or elevated PaO2 in neonates warrants consideration of methemoglobinemia.