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Related Experiment Video

Updated: Jan 22, 2026

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Ultrasound Controlled-Release Hydrogel Promotes Diabetic Wound Healing via Neuroimmune Modulation and Synergistic ROS

Mofan Li1, Mengxin Wang1, Haonan Wang1

  • 1Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 21, 2026
PubMed
Summary

This study developed an ultrasound-triggered hydrogel system delivering targeted nanoparticles to treat diabetic wounds. The system enhances healing by modulating neuroimmune signals and scavenging reactive oxygen species for improved blood supply and collagen deposition.

Keywords:
calcitonin gene‐related peptidediabetic woundneuroimmune modulationultrasound‐responsive

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Area of Science:

  • Biomaterials Science
  • Nanomedicine
  • Regenerative Medicine

Background:

  • Diabetic wounds (DW) present significant clinical challenges due to high morbidity and disability.
  • Existing therapies often overlook neuropeptide-mediated neuroimmune communication, a key factor in wound healing.
  • Precise and controlled drug delivery is crucial for effective diabetic wound treatment.

Purpose of the Study:

  • To develop an advanced therapeutic system for diabetic wound healing.
  • To integrate neuroimmune modulation and reactive oxygen species (ROS) scavenging capabilities.
  • To create an ultrasound-responsive, targeted delivery platform for on-demand drug release.

Main Methods:

  • Constructed amphiphilic prodrug molecule MC (calcitonin gene-related peptide (CGRP) + manganese porphyrin (MnP)).
  • Co-assembled MC with DSPE-PEG-folic acid (FA) into targeted nanoparticles (MCF).
  • Loaded MCF into an ultrasound-responsive hydrogel (MCF@CA) for controlled release.

Main Results:

  • MCF@CA system demonstrated ultrasound-triggered on-demand release of MCF nanoparticles.
  • FA targeting enhanced M1 macrophage interaction and prolonged wound retention.
  • MnP effectively scavenged ROS, improved fibroblast function, and promoted anti-inflammatory macrophage polarization.
  • MCF@CA combined with ultrasound significantly promoted diabetic wound healing in animal models, evidenced by enhanced collagen deposition, immune modulation, and improved blood supply.

Conclusions:

  • The MCF@CA system offers a novel, on-demand controlled delivery platform for diabetic wound therapy.
  • This approach effectively integrates neuroimmune regulation and ROS scavenging for enhanced healing.
  • The developed system shows significant translational potential for clinical application in diabetic wound management.