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Intelligent Soft Opto-Magnetic Robot for Minimally Invasive Interventional Therapy.

Jingjing Guo1,2, Xiaoyan Guo1, Jian Wei3

  • 1School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 21, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed an intelligent soft opto-magnetic (iSOM) robot for minimally invasive interventions. This millimeter-scale robot integrates tactile sensing and photothermal ablation, enhancing precision and safety in complex procedures.

Keywords:
minimally invasive interventionsoptical tactile sensorphotothermal ablation therapysoft robotics

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Area of Science:

  • Biomedical Engineering
  • Robotics
  • Surgical Technology

Background:

  • Minimally invasive interventions (MII) offer benefits but face limitations like lack of tactile feedback and reliance on radiation imaging.
  • Current MII technologies struggle with dexterity in confined spaces and real-time sensory feedback.
  • Multifunctional miniature robots are needed to overcome these barriers in MII.

Purpose of the Study:

  • To introduce a novel intelligent soft opto-magnetic (iSOM) robot for advanced MII.
  • To integrate magnetic actuation, tactile sensing, and photothermal ablation into a single millimeter-scale device.
  • To enhance precision, safety, and therapeutic delivery in MII.

Main Methods:

  • Designed a millimeter-scale soft robot with a polymer sheath, optical pathways, and a magnetically steerable body.
  • Integrated skin-mimic tactile sensing for feedback and photothermal ablation capabilities.
  • Utilized magnetic fields for navigation and laser excitation for therapy, enabling real-time monitoring.

Main Results:

  • Demonstrated active navigation through tortuous anatomy using magnetic fields.
  • Successfully performed targeted photothermal ablation therapy with real-time feedback.
  • Validated capabilities in porcine tissue, cardiovascular phantoms, and ex vivo/in vivo anatomical systems.

Conclusions:

  • The iSOM robot successfully integrates multiple functionalities for high-precision MII.
  • The device offers enhanced navigation, tactile feedback, and targeted therapeutic delivery.
  • The iSOM robot shows significant translational potential for improving MII outcomes.