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Reduced Environmental Stimulation Therapy (REST) in methamphetamine use disorder: a pilot study.

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This summary is machine-generated.

Reduced Environmental Stimulation Therapy (REST) shows promise for methamphetamine use disorder (MUD). A single pool-REST session was feasible, safe, and well-tolerated, reducing negative affect and craving.

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Area of Science:

  • Psychiatry
  • Addiction Medicine
  • Psychology

Background:

  • Current treatments for methamphetamine use disorder (MUD) are insufficient for withdrawal management and relapse prevention.
  • Negative affect is a significant factor in drug craving and relapse.
  • Reduced Environmental Stimulation Therapy (REST) has shown efficacy in reducing negative affect in other conditions but not MUD.

Purpose of the Study:

  • To investigate the feasibility, tolerability, and safety of a single session of REST using a floatation pool (pool-REST) in individuals with MUD.
  • To compare the effects of pool-REST with a chair-REST active comparator on affect, interoception, and craving.

Main Methods:

  • A within-subject crossover design was employed with 78 participants diagnosed with MUD.
  • Participants completed one session each of pool-REST and chair-REST.
  • Feasibility, tolerability, and safety were assessed through completion rates, duration of use, and adverse events. Secondary outcomes included self-reported affect, interoceptive sensation, and stimulant craving.

Main Results:

  • 74% of participants completed both REST sessions, indicating good feasibility.
  • Sessions were well-tolerated with no serious adverse events reported.
  • Both conditions reduced stress, negative affect, and craving; pool-REST showed greater increases in positive affect and cardiorespiratory interoceptive awareness.

Conclusions:

  • REST sessions, particularly pool-REST, are feasible, well-tolerated, and safe for individuals with MUD.
  • Preliminary findings suggest potential benefits of pool-REST in improving positive affect and interoceptive awareness.
  • Further randomized controlled trials are recommended to confirm the efficacy of pool-REST for MUD remission and recovery.