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Systemic inflammatory indices mediate the association between hyperuricemia and left ventricular hypertrophy:

Jingyuan Li1, Yang Xu1, Ruting Li2

  • 1Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, China.

Frontiers in Endocrinology
|January 21, 2026
PubMed

Insights

Systemic inflammation, measured by SII and SIRI, is linked to left ventricular hypertrophy (LVH) in patients with hyperuricemia (HUA). These inflammation markers partially explain how high urate levels affect cardiac remodeling.

Area of Science:

  • Cardiology
  • Inflammation research
  • Metabolic disorders

Background:

  • Hyperuricemia (HUA) is linked to left ventricular hypertrophy (LVH), a cardiac injury marker.
  • Systemic inflammation is implicated in ventricular remodeling.
  • Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) may quantify inflammation.

Purpose of the Study:

  • To investigate the association between SII, SIRI, and LVH in HUA patients.
  • To explore the role of systemic inflammation in the relationship between serum urate and LVH.

Main Methods:

  • Analysis of 3,632 HUA patients, excluding those with hypertension, diabetes, or advanced CKD.
  • Calculation and log-transformation of SII and SIRI, followed by k-means clustering.
  • Logistic regression, restricted cubic spline, and mediation analyses to assess associations and pathways.

Main Results:

  • 12.5% of patients had LVH, associated with older age, female sex, higher SBP, urate, glucose, SII, SIRI, and lower eGFR, LVEF.
  • Elevated SII and SIRI were independently associated with LVH.
  • Systemic inflammation partially mediated the urate-LVH relationship (11.9% for SII, 29.9% for SIRI).

Conclusions:

  • SII and SIRI are positively correlated with LVH in HUA patients.
  • Systemic inflammation plays a partial mediating role in the urate-LVH relationship.
  • Highlights inflammation's importance in hyperuricemia-related cardiovascular disease.
Abstract

Keywords:
hyperuricemialeft ventricular hypertrophy (LVH)systemic immune-inflammation index (SII)systemic inflammationsystemic inflammation response index (SIRI)

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