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Cefiderocol Elimination During Peritoneal Dialysis: A Short Report
Julian Müller-Kühnle1, Bettina Rittershofer2, Moritz Schanz1
1Department of General Internal Medicine and Nephrology, Robert Bosch Hospital, Stuttgart, DEU.
Cefiderocol shows moderate removal during peritoneal dialysis (PD), less than hemodialysis (HD). Therapeutic drug monitoring may optimize cefiderocol dosing for PD patients, balancing efficacy and safety.
Area of Science:
- Pharmacology
- Nephrology
- Infectious Diseases
Background:
- Cefiderocol, a siderophore cephalosporin, is effective against multidrug-resistant Gram-negative bacteria.
- Pharmacokinetic data for cefiderocol in patients undergoing peritoneal dialysis (PD) are currently limited.
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Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...

