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Updated: Jan 22, 2026

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
Published on: June 7, 2018
Single-cell sequencing reveals the tumor immune microenvironment in thyroid cancer: a narrow review
Kangcong Liang1,2, Ziyu Wang2, Zhiqiang Zhang1,3
1Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China.
Abstract:
The immune microenvironment profoundly shapes the progression and therapeutic response of thyroid carcinoma. Through comprehensive analysis of single-cell RNA sequencing data, this review delineates the immune landscapes of papillary thyroid carcinoma (PTC), poorly differentiated thyroid carcinomas (PDTC), and anaplastic thyroid carcinomas (ATC), revealing a differentiation dependent trajectory of tumor immune microenvironment remodeling-from immune activation suppression coexistence in PTC, to immune exclusion in PDTC, and terminal exhaustion in ATC. This single-cell based approach enables high resolution dissection of cellular heterogeneity, immune crosstalk, and spatial organization that are often masked in bulk analyses. Such insights provide a scientific basis for precision immunotherapy, offering guidance for differentiation tailored strategies to overcome immune escape and improve clinical outcomes in thyroid cancer.
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