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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

382
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
382
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

221
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
221
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

182
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
182
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

274
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
274
Induced-fit Model01:13

Induced-fit Model

88.9K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Related Experiment Video

Updated: Jan 22, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

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Cyclophosphamide-Induced Hemorrhagic Myocarditis.

Rade R Jibawi Rivera1, David M Harmon2, Joerg Herrmann2

  • 1Deparment of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

JACC. Case Reports
|January 21, 2026
PubMed
Summary
This summary is machine-generated.

Cyclophosphamide can cause rare hemorrhagic myocarditis even at doses below 100 mg/kg. Early cardiac imaging is crucial for diagnosing this nonfatal cardiotoxicity.

Area of Science:

  • Cardiology
  • Oncology
  • Pharmacology

Background:

  • Cyclophosphamide is a common chemotherapy drug.
  • It can cause various toxicities, including rare hemorrhagic myocarditis.
Keywords:
acute heart failurecancercardiac magnetic resonancecardiomyopathyechocardiographyimagingleft ventricleperipheral edemasupraventricular arrhythmias

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  • This case presents a nonfatal instance of this toxicity.