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Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry
Published on: April 9, 2021
Direct Difunctionalization of Unsaturated Peptides: A Strategy for Concurrent Incorporation of Trifluoromethyl and
Xing-Xing Ding1, Ting-Ting Feng1, Lin Dong1
1Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Abstract:
The simultaneous incorporation of alkyne and trifluoromethyl groups into peptides enables rapid access to multifunctional peptide structures. Herein, we report the first metal-free trifluoromethylalkynylation of unsaturated amino acids and peptides using a cheap trifluoromethylation reagent under mild conditions, offering a practical and versatile route to valuable scaffolds.
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