Greater sphenoid wing infarction in sickle cell disease

A 19-year-old male with a history of sickle cell disease (type SS) was seen for left upper eyelid edema during an admission for sickle cell crisis. Magnetic resonance imaging revealed T2 hyperintensity and diffusion restriction within the left greater wing of the sphenoid, corresponding to orbital bony infarction, a rare orbital manifestation of sickle cell disease. We present a case of left greater sphenoid wing infarction in the setting of sickle cell vasoocclusive crisis successfully managed with medical therapy.