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Updated: Jan 23, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Divergent Access to α,β-Unsaturated Thiolated and Selenolated Lactams via a Unified Palladium-Catalyzed Carbonylative
Zhiping Yin1, Shuhui Sun1, Xiaowen Qin1
1School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Abstract:
Herein, a unified and divergent palladium-catalyzed carbonylative procedure for the direct synthesis of α,β-unsaturated thiolated and selenolated lactams is reported. This strategy enables the simultaneous construction of the lactam core and installation of valuable sulfur or selenium functionalities via a single catalytic operation. By employing simple propargylamine substrates together with diphenyl disulfide or diselenide under a carbon monoxide atmosphere, the corresponding lactams were formed in moderate to good yields with promising functional group tolerance.
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