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Updated: Jan 23, 2026

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
Published on: July 13, 2019
BK and JC polyomavirus co-infection resulting in polyomavirus nephropathy and progressive multifocal
Sébastien Briol1, Laura Labriola2, Arnaud Devresse2
1Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Department of Internal Medicine and Infectious Diseases, Brussels, Belgium.
Abstract:
John Cunningham Virus (JCV) and BK Virus (BKV) are the most extensively studied Human Polyomaviruses (HPyVs), primarily associated with Progressive Multifocal Leukoencephalopathy (PML) and BKV Nephropathy (BKVN), respectively. While co-infection with these viruses has been documented in the same disease, simultaneous manifestation in distinct pathologies has not been previously reported. We present the first documented case of concurrent PML and Polyomavirus Nephropathy (PVN) due to reactivation of two different HPyVs, offering new insights into the clinical spectrum of HPyV-related diseases.
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