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Updated: Jan 23, 2026
08:07
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
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HLA typing challenges in organ donation after transplant
Nathan A Lemp1, Peter Lalli2, Sara O Dionne1
1Eurofins Donor & Product Testing, LLC, Centennial, CO, USA.
Human Immunology
|January 21, 2026
Summary
Organ donation after transplant requires complete clinical communication. Timely disclosure of donor transplant history is crucial for accurate human leukocyte antigen (HLA) typing and efficient organ allocation.
Area of Science:
- Transplantation immunology
- Histocompatibility testing
Background:
- Accurate human leukocyte antigen (HLA) typing is critical for successful organ donor-recipient matching.
- Undisclosed donor clinical histories can complicate laboratory procedures and donor allocation.
Purpose of the Study:
- To highlight challenges in HLA typing for organ donors with recent transplant histories.
- To emphasize the importance of complete clinical communication in organ donation.
Main Methods:
- Case report of two deceased organ donors with recent transplants (liver and lung).
- Investigation of failed HLA typing from peripheral blood specimens.
- Utilized buccal swabs and pre-transplant HLA typing for donor identification.
Main Results:
- Peripheral blood HLA typing failed in both cases of Organ Donation After Transplant (ODAT).
- Prior transplant status was initially undisclosed to laboratory personnel.
- Buccal swabs and pre-transplant data were essential for successful HLA typing.
Conclusions:
- Complete and timely communication between organ procurement and histocompatibility labs is vital.
- Lack of disclosure regarding prior transplants can cause significant delays.
- Improved communication enhances safety and efficiency in organ donor allocation.
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